EXTRATO HIDROETANÓLICO DE GENGIBRE (ZINGIBER OFFICINALE) INIBE A OXIDAÇÃO DA LIPOPROTEÍNA DE BAIXA DENSIDADE (LDL), IN VITRO
DOI:
https://doi.org/10.21527/2176-7114.2020.39.19-26Keywords:
Antioxidante. Aterosclerose. Hipercolesterolemia. Produtos Naturais. Estresse Oxidativo.Abstract
Purpose: Considering LDL oxidation as a crucial factor in the development of atherosclerosis, and the antioxidant, anti-inflammatory and anti-angiogenic properties of ginger (Zingiber officinale), the aim of the present study is to evaluate the phytochemical content, antioxidant mechanisms and the potential of Ginger Rhizome Hydroethanolic Extract (EHEG), on low density lipoprotein (LDL) oxidation of hypercholesterolemic patients, in vitro. Method: In EHEG were evaluated contents of phytochemical compounds and antioxidant mechanisms. From patient serum samples (n = 12), the LDL fraction was isolated, previously treated with EHEG (10 - 100 µg / ml) and subjected to oxidative induction with AAPH (10 mM). Afterwards, the lipoperoxidation level was measured. Results: EHEG has total phenolic compounds (357.68 ± 39.80 mg AG / g), flavonoids (30.37 ± 5.10 mg Q / g), tannins (51.99 ± 11.88 mg CA / g ) and vitamin C (21.53 ± 1.43 mg Vit C / g), besides presents NO (IC50 = 40.53 μg / mL) and H2O2 (IC50 = 1.42 mg / mL) radical scavenging activity. Regarding inhibition of LDL oxidation, it was observed that the EHEG, from the concentration of 50 µg/ml was effective in reducing the oxidative damage caused by AAPH. Conclusion: Ginger has protective activity against the formation of oxidized LDL, suggesting that its phytochemical compounds confer antioxidant activity, and may be effective in the prevention and/or treatment of cardiovascular diseases, especially those related to the process of atherosclerosis.
Downloads
Published
Issue
Section
License
By publishing in Revista Contexto & Saúde, authors agree to the following terms:
The works are licensed under the Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) license, which allows:
Share — to copy and redistribute the material in any medium or format;
Adapt — to remix, transform, and build upon the material for any purpose, including commercial.
These permissions are irrevocable, provided that the following terms are respected:
Attribution — authors must be properly credited, with a link to the license and indication of any changes made.
No additional restrictions — no legal or technological measures may be applied that restrict the use permitted by the license.
Notes:
The license does not apply to elements in the public domain or covered by legal exceptions.
The license does not grant all rights necessary for specific uses (e.g., image rights, privacy, or moral rights).
The journal is not responsible for opinions expressed in the articles, which are the sole responsibility of the authors. The Editor, with the support of the Editorial Board, reserves the right to suggest or request modifications when necessary.
Only original scientific articles presenting research results of interest that have not been published or simultaneously submitted to another journal with the same objective will be accepted.
Mentions of trademarks or specific products are intended solely for identification purposes, without any promotional association by the authors or the journal.
License Agreement (for articles published from September 2025): Authors retain copyright over their article and grant Revista Contexto & Saúde the right of first publication.
