COMORBIDADES ENTRE PACIENTES COM ARTRITE REUMATOIDE E SUA ASSOCIAÇÃO COM A DESCOMPENSAÇÃO CLÍNICA

COMORBIDITIES AMONG PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR ASSOCIATION WITH CLINICAL DECOMPENSATION

Authors

DOI:

https://doi.org/10.21527/2176-7114.2021.44.12356

Keywords:

Arthritis, Rheumatoid, Comorbidity, Disease management, Diabetes mellitus, Age

Abstract

Rheumatoid arthritis (RA) is a inflammatory, chronic disease, which can bring several consequences to the individual. Patients with RA can present several comorbidities that may influence the clinical evolution of RA. Objective: evaluate the association between comorbidities and the RA activity profile among patients attending a rheumatology clinic of a public university hospital. Methods: this is a cross-sectional study, which collected demographic, diseases, lifestyle habits and RA profile data from a representative sample of patients with RA attending the outpatient clinic. A descriptive analysis of these data was performed, as well as univariate and multivariate analyzes to evaluate factors associated with the DAS28 (Disease Activity Score 28). Results: two hundred and one patients were included, a female majority (85.6%; n = 172) was detected and the mean age was 60.3 ± 11.5. Seven patients (3.5%) were obese, 17 (8.5%) smokers, 106 (52.7%) hypertensive, 38 (18.9%) diabetic and 72 (35.8%) had dyslipidemia. A mean functional comorbidity index of 2.3 ± 1.19 were identified in the sample. Age equal or greater than 60 years (OR = 0.40, 95% CI 0.21-0.74) and be diabetic (OR = 2.96, 95% CI, 30-6,74) were statistically significantly associated with moderate or high DAS28. Conclusion: the presence of comorbidities was frequent among patients with RA. Furthermore, age equal to or greater than 60 years was negatively associated, and a diagnosis of diabetes mellitus (DM) positively associated with moderate to high disease activity according. The findings reinforce the need for DM monitoring among these patients, especially the younger ones.

Author Biography

Thuane Sales Gonçalves, Programa de Pós-graduação em Farmacologia da Escola Paulista de Medicina/Unifesp

Possui graduação em Farmácia pela UFMG, atualmente é bolsista no Programa de Pós-graduação em Farmacologia da Escola Paulista de Medicina/Unifesp. Possui experiência em farmácia clínica e hospitalar com ênfase em atenção farmacêutica e gerenciamento da terapia medicamentosa. Foi bolsista de Iniciação Científica da Fundação Ezequiel Dias (FUNED), com participação na linha de pesquisa: Abordagem Molecular e Imunológica das Neoplasias Ginecológicas. Participa do grupo de pesquisa Biologia Molecular e Imunologia do Câncer Ginecológico (UFMG) e colabora com atividades do Centro de Estudos em Atenção Farmacêutica (UFMG).

Published

2022-02-18

How to Cite

de Carvalho Fernandes, A. C. ., Sales Gonçalves, T., Mathyell Silva, H. ., de Morais Neves, C., Viana Oliveira, I., Ramalho de Oliveira, D., Maria Kakehasi, A. ., Costa Pinto, M. R. ., & Martins Gonzaga do Nascimento, M. (2022). COMORBIDADES ENTRE PACIENTES COM ARTRITE REUMATOIDE E SUA ASSOCIAÇÃO COM A DESCOMPENSAÇÃO CLÍNICA: COMORBIDITIES AMONG PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR ASSOCIATION WITH CLINICAL DECOMPENSATION. Context and Health Journal, 21(44), 375–384. https://doi.org/10.21527/2176-7114.2021.44.12356

Issue

Section

Contexto & Saúde - Geral