Health-related quality of life and associated factors in people undergoing liver transplantation
DOI:
https://doi.org/10.21527/2176-7114.2024.48.14524Keywords:
Quality of life, liver transplant, health, physical exercise, mental healthAbstract
Objective: To analyze the quality of life (QoL) and associated factors in people undergoing liver transplantation in southern Brazil. Methods: Exploratory cross-sectional study. The dependent variables were the QoL domains collected through the Short Form Quality of Life questionnaire–36. The independent variables were sex, age, marital status, education, income, employability, physical exercise, and years since transplantation, etiology and comorbidities. In the analysis, p<0.05 was considered. Results: The sample was made up of 226 people. The QoL domains that scored the most were Emotional Aspect, Social Aspect and Functional Capacity, and those that scored the least were Pain, Physical Aspect and Vitality. Being female was associated with lower scores in Functional Capacity, Vitality and Social Role. Lower income was associated with lower scores on the Emotional Aspect and being retired, the lowest score on Vitality. The number of comorbidities was negatively associated with the General State of Health and Vitality. Mental Health disease reduces the values of Vitality, Social Aspect, Emotional Aspect and Mental Health. Exercising after the transplant was associated with higher values for Pain, Physical Appearance, Functional Capacity, Vitality, Emotional Appearance and Mental Health. Conclusions: This sample presented a more satisfactory perception of the QoL Emotional and Social Aspect and Functional Capacity domains. Factors negatively related to the quality of life were being female, having an income of less than R$ 3.000, not working, number of comorbidities present at the time of the interview, and diagnosing a mental health illness, on the other hand, practicing physical exercise after the transplant was positively related.
References
World Health Organization Quality of Life Assessment. Position paper from the World Health Organization. In: Orley J, Kuyken W. Quality of life assessment: international perspectives. Heidelberg: Springer Verlag; 1995.
Aguiar MIF, Alves NP, Braga VAB, Souza AMA, Araújo MAM, Almeida PC. Psychosocial aspects of the quality of life of liver transplant recipients. Texto & Contexto - Enferm. 2018;27(2):e3730016.Haraldstad K, Wahl A, Andenaes R, Andersen JR, Andersen MH, Beisland E,.et al. A systematic review of quality-of-life research in medicine and health sciences. Qual Life Res. 2019;28:2641-50.
Minayo MCS, Hartz ZMA, Buss PM. Quality of life and health: a necessary debate. Cienc Saúde Coletiva. 2000;5(1):7-18.European Association for the Study of the Liver. EASL clinical practice guidelines: Liver transplantation. J Hepatol. 2016;64(2):433-85.
Trotter JF. Liver transplantation around the world. Curr Opin Organ Transplant. 2017;22(2):123-7.
Dove LM, Brown RS. Liver transplantation in adults: Patient selection and pretransplant evaluation. 2021. UptoDate [internet]. 2022 [cited 2022 may 01]. Available from: https://www.medilib.ir/uptodate/show/4585
Mendes KDS, Lopes NLC, Fabbris MA, Castro-e-Silva Júnior O, Galvão CM. Sociodemographic and clinical characteristics of candidates for liver transplantation. Acta Paul Enferm. 2016;29(2):128-35.
Peng J-K, Hepgul N, Higginson IJ, Gao W. Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis. Palliat Med. 2019;33(1):24-36.
Onghena L, Develtere W, Poppe C, Geerts A, Troisi R, Vanlander A, et al. Quality of life after liver transplantation: state of the art. World J Hepatol. 2016;8(18):749-56.
Shamsaeefar A, Nikeghbalian S, Kazemi K, Gholami S, Sayadi M, Fatemeh A, et al. Quality of life among liver transplantation recipients before and after surgery: A single-center longitudinal study. Indian J Transplant. 2020;14(1):48-52.
Girgenti R, Tropea A, Buttafarro MA, Ragusa R, Ammirata M. Quality of life in liver transplant recipients: A retrospective study. Int J Environ Res Public Health. 2020;17(11):3809.
Aberg F. Quality of life after liver transplantation. Best Pract Res Clin Gastroenterol. 2020;46-47:101684.
Garcia CS. Quality of life, social support and the impact on the family of pre- and post-liver transplant patients. PhD Thesis - State University of Campinas, School of Medical Sciences, Campinas [internet]; 2018 [cited 2022 feb 21]. Available from: https://bdtd.ibict.br/vufind/Record/UNICAMP-30_43b9fc6ea6cadf7810dcb0fe8980c139
Silva GSA, Costa e Castro BM, Franco CCC, Escher DR, Franco LC, Tannús LMS, et al. Impacts on the quality of life of patients after liver transplantation. REAC. 2021;23:1-6.
McLean KA, Drake TM, Sgro A, Camilleri-Brennan J, Knight SR, Ots R, et al. The effect of liver transplantation on patient-centred outcomes: A propensity-score matched analysis. Transpl Int. 2019;32:808-19.
Jover-Aguilar M, Martínez-Alarcón L, Ramis G, Pons JÁ, Ríos A, Febrero B, et al. Resilience related to quality of life perceived in elderly patients with orthotopic liver transplant for more than 10 years. Transplant Proc. 2020;52(5):1511-3.
Mendoza-Sánchez F, Ramírez-González LR, Reyes-Cruz AA, González-Ojeda A, Hernández-Machuca JS, Fuentes-Orozco C. Evaluación de la calidad de vida en pacientes con trasplante hepático. Rev Med Inst Mex Seguro Soc. 2016;54(2):176-81.
Nogueira IR, Coelho JCU, Domingos MF, Parolin MB, Matias JEF, Freitas ACT, et al. Good quality of life after more than a decade of living donor liver transplantation. Arq Gastroenterol. 2021;58(01):10-6.
Onghena L, Berrevoet F, Vanlander A, Vlierberghe HV, Verhelst X, Hoste E, et al. Illness cognitions and health-related quality of life in liver transplant patients related to length of stay, comorbidities and complications. Qual Life Res. 2022;31(8):2493-504.
Tamer M, Yava A. The quality of life of patients after liver transplantation. Annals Med Res. 2022;29(2):139-43.
Fazekas C, Kniepeiss D, Arold N, Matzer F, Wagner-Skacel J, Schemmer P. Health-related quality of life, workability, and return to work of patients after liver transplantation. Langenbecks Arch Surg. 2021;406(6):1951-61.
Saab S, Bownik H, Ayoub N, Younossi Z, Durazo F, Han S. et al. Differences in health-related quality of life scores after orthotopic liver transplantation with respect to selected socioeconomic factors. Liver Transpl. 2011;17(5):580-90.
Aguiar MIF, Braga VAB, Garcia JHP, Lima CA, Almeida PC, Alves e Souza AM, et al. Quality of life in liver transplant recipients and the influence of sociodemographic factors. Rev Esc Enferm USP. 2016;50(3):411-8.
Whang Z, Li N, Lin D. Impact of metabolic syndrome on quality of life of liver transplant recipients. J Int Med Res. 2018;46(9):3778-87.
Cristin DJ, Forman LM, Jackson WE. Beyond survival: targeting health‐related quality of life outcomes after liver transplantation. Clin Liver Dis. 2021;17(5):359-64.
Santa Isabel Hospital. Liver transplant protocol. 2020. Mimeo.
Openepi. Open source statistics for Public Health [internet]. 2023 [cited 2023 feb 21]. Available from: http://www.openepi.com/SampleSize/SSPropor.htm.
Ware Jr JE, Sherbourne CD. The MOS 36-Item Short-Form Health Survey (SF-36): I. Conceptual framework and item selection. Med Care. 1992;30(6):473-83.
Ciconelli RM, Ferraz MB, Santos W, Meinão I, Quaresma MR. Translation into Portuguese and validation of the generic quality of life assessment questionnaire SF36 (BRASIL-SF-36). Rev Bras Reumatol. 1999;39(3):143-50.
Parenti T. Biostatistics. Group A [internet]. 2018 [cited 2022 dec 23]. Available from: https://integrada.minhabiblioteca.com.br/books/9788595022072.
Hair Jr JF, Black WC, Babin BJ, Anderson RE, Tatham RL. Multivariate data analysis. 5. ed. Porto Alegre: Bookman; 2005.
Silva MMC, Silva AMO, Corcha RA, Franco FBZ, Zorrer LABF, Boin IFSF, et al. Improvement of physical capacity and quality of life after liver transplantation: A longitudinal study. Hepat Mon. 2019;19(8):e88018.
Nikam V, Ramaswamy V, Chaudhary A, Singhvi S. Effect of orthotopic liver transplantation on the health-related quality of life in Indian patients with end-stage liver disease: A prospective study. J Surg Res. 2022;5(3):435-40.
Silva JD. The impact of liver disease and liver transplantation on quality of life. Dissertation (Master of Science) - Faculty of Medicine, University of São Paulo, São Paulo; 2017.
Legendre C, Viebahn R, Crespo M, Dor F, Gustafsson B, Samuel U, et al. Beyond survival in solid organ transplantation: A summary of expert presentations from the Sandoz 6th Standalone Transplantation Meeting, 2018. Transplantation. 2019;103(9 sup. 1):S1–S13.
Yang LS, Shan LL, Saxena A, Morris DL. Liver transplantation: A systematic review of long-term quality of life. Liver Int. 2014;34(9):1298-313.
Loduca A, Müller BM, Focosi AS, Samuelian C, Yeng LT. Retrato da dor: Um caminho para entender o sofrimento do indivíduo. Psic: Teor e Pesq. 2021;37.
Costa JM, Nogueira LT. Association between work, income and quality of life of kidney transplant recipient the municipality of Teresina, PI, Brazil. J Bras Nefrol. 2014;36(3):332-8.
Nordenfelt L. Conversando sobre saúde: Um diálogo filosófico. Florianópolis: Bernuncia Editora; 2001.
Ribeiro PAB, Gradassi M, Martin S-M, Leenknegt J, Baudet M, Le VV, et al. Clinical implementation of different strategies for exercise-based rehabilitation in kidney and liver transplant recipients: A pilot study. Arq Bras Cardiol. 2022;119(2):246-54.
Burra P, Ferrarese A. Health-related quality of life in liver transplantation: Another step forward. Transpl Int. 2019;32(8):792-3.
Leite AMC, Sousa, PSA, Costa JR, Melo RA, Carvalho FO, Moura JC. Factors related to the quality of life of transplant patients. Rev Cuid. 2019;10(2):e715.
Kelly R, Hurton S, Ayloo S, Cwinn M, Coutere-Bosse S, Molinari M. Societal reintegration following cadaveric orthotopic liver transplantation. Hepatobiliary Surg Nutr. 2016;5(3):234-44.
Weng LC, Huang HL, Wang YW, Lee WC, Chen KH, Yang TY. The effect of self-efficacy, depression and symptom distress on employment status and leisure activities of liver transplant recipients. J Adv Nurs. 2014;70(7):1573-83.
Paglione HB, Oliveira PC, Mucci S, Roza BA, Schirmer J. Quality of life, religiosity and anxious and depressive symptoms in liver transplant candidates. Rev Esc Enferm USP. 2019;53:e03459.
Gruttadauria S, Grosso G, Mistretta A, Pagano D, Scianna G, Vizzini GB, et al. Impact of recipients’ socio-economic status on patient and graft survival after liver transplantation: the IsMeTT experience. Dig Liver Dis. 2011;43(11):893-8.
Aguiar MIF, Braga VAB, Almeida PC, Garcia JHP, Lima CA. Severity of liver disease and quality of life in liver transplantation. Acta Paul Enferm. 2016;29(1):107-14.
Ziviani LC, Mendes KDS, Matins-Pedersoli T, Molina FMR, Galvão CM. Information needs of liver transplant recipients. BJT. 2021;24(1):15-23.
VanWagner LB, Uttal S, Lapin B, Lee J, Jichlinski A, Subramanian T, el al. Use of six-minute walk test to measure functional capacity after liver transplantation. Phys Ther. 2016;96(9):1456-67.
Domingos MF, Coelho JCU, Nogueira IR, Parolin MB, Matias JEF, de Freitas ACT, et al. Quality of life after 10 years of liver transplantation. J Gastrointestin Liver Dis. 2020;29(4):611-6.
Sainz-Barriga M, Baccarani U, Scudeller L, Risaliti A, Toniutto PL, Costa MG, et al. Quality-of-life assessment before and after liver transplantation. Transplant Proc. 2005;37(6):2601-4.
Faustino AM, Neves R. Benefits of practicing physical activity in the elderly: Literature review. REAS. 2020;12(5):e3012.
Kotarska K, Wunsch E, Kempinska-Podhorodecka A, Raszeja-Wyszomirska J, Bogdanos DP, Wójcicki M, et al. Factors affecting health-related quality of life and physical activity after liver transplantation for autoimmune and nonautoimmune liver diseases: A prospective, single centre study. J Immunol Res. 2014;2014:738297.
Gautério LP. The benefits of physical exercise for transplant patients. BJT.2018;21(3):17-22.
De Lima SM, De Figueiredo BQ, Safatle GCB. Metabolic syndrome and the role of physical activity in the clinical approach to associated comorbidities. RSD. 2022;11(9):e56611932322.
Jetten WD, Hogenbirk RNM, Van Meeteren NLU, Cuperus FJC, Klaase JM, De Jong R. Physical effects, safety and feasibility of prehabilitation in patients awaiting orthotopic liver transplantation, a systematic review. Transpl Int. 2022;35:10330.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Revista Contexto & Saúde
This work is licensed under a Creative Commons Attribution 4.0 International License.
Autores que publicam na Revista Contexto & Saúde concordam com os seguintes termos:
a) A submissão de trabalho(s) científico(s) original(is) pelos autores, na qualidade de titulares do direito de autor do(s) texto(s) enviado(s) ao periódico, nos termos da Lei 9.610/98, implica na cessão de direitos autorais de publicação na Revista Contexto e Saúde do(s) artigo(s) aceitos para publicação à Universidade Regional do Noroeste do Estado do Rio Grande do Sul, autorizando-se, ainda, que o(s) trabalho(s) científico(s) aprovado(s) seja(m) divulgado(s) gratuitamente, sem qualquer tipo de ressarcimento a título de direitos autorais, por meio do site da revista e suas bases de dados de indexação e repositórios, para fins de leitura, impressão e/ou download do arquivo do texto, a partir da data de aceitação para fins de publicação. Isto significa que, ao procederem a submissão do(s) artigo(s) à Revista Contexto e Saúde e, por conseguinte, a cessão gratuita dos direitos autorais relacionados ao trabalho científico enviado, os autores têm plena ciência de que não serão remunerados pela publicação do(s) artigo(s) no periódico.
b). Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
c). Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
d. Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado (Veja O Efeito do Acesso Livre).
