Clinical and epidemiological overview of tuberculosis in a health region in the Brazilian amazon
DOI:
https://doi.org/10.21527/2176-7114.2024.48.14750Keywords:
Disease Notification, Epidemiological Monitoring, Geographic Mapping, Health Strategies, VaccinationAbstract
Introduction: Tuberculosis is one of the main global health problems, in addition to being one of the main causes of death by infectious agent. Objectives: To describe the clinical-epidemiological profile of tuberculosis and the relationship with the level of vaccination coverage among the municipalities of the 12th regional health center in the State of Pará. Materials and Methods: This is an ecological retrospective study, carried out with clinical data -epidemiological data from the Notifiable Diseases Information System. For data analysis, descriptive and inferential statistics were applied. Results: During the analyzed period (2012-2022), 1330 cases of tuberculosis were registered in the region. And considering the geographic distribution, only one municipality had most cases, Redenção with 34.8% (464/1330). In addition, considering sociodemographic analyses, it was noted that the cases were concentrated in brown individuals 52.1% (693/1330), men 64.2 (855/1330), aged between 20-59 years 64.3% (856 /1330) and incomplete primary education 56.3% (750/1330). Low adherence to performing bacteriological culture and resistance screening was evidenced. Conclusions: It was possible to delineate the global epidemiological profile of tuberculosis cases in the Araguaia health region. Regarding the geographic distribution, it was possible to evidence the centralization of notifications in a single municipality. Low adherence to complementary tests suggests the need to improve the autonomy of municipalities, aiming at assertive diagnosis and treatment and mitigation of damage to the health of affected patients.
References
Tortora GJ, Funke BR, Case CL. Microbiologia. 12th ed. Porto Alegre: Artmed; 2017.
Bogliolo L, Brasileiro Filho G. Patologia. 10th ed. Rio de Janeiro: Guanabara Koogan; 2021.
Chen J, Gao L, Wu X, Fan Y, Liu M, Peng L, et al. BCG-induced trained immunity: history, mechanisms and potential applications. J Transl Med. 2023;21(1):106-115. DOI: https://doi.org/10.1186/s12967-023-03944-8
Arroyo LH, Ramos ACV, Yamamura M, Weiller TH, Crispim J de A, Cartagena-Ramos D, et al. Áreas com queda da cobertura vacinal para BCG, poliomielite e tríplice viral no Brasil (2006-2016): mapas da heterogeneidade regional. Cad Saúde Pública [Internet]. 2020;36(4):e00015619. DOI: https://doi.org/10.1590/0102-311X00015619
Fukunaga R, Glaziou P, Harris JB, Date A, Floyd K, Kasaeva T. Epidemiology of Tuberculosis and Progress Toward Meeting Global Targets – Worldwide, 2019. MMWR Morb Mortal Wkly Rep. 2021 Mar 26;70(12):427-430. DOI: 10.15585/mmwr.mm7012a4
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Tuberculose. Boletim epidemiológico especial. Brsília: Ministério da Saúde; 2021.
Martins-Melo FR, Bezerra JMT, Barbosa DS, Carneiro M, Andrade KB, Ribeiro ALP, et al. The burden of tuberculosis and attributable risk factors in Brazil, 1990-2017: results from the Global Burden of Disease Study 2017. Popul Health Metr. 2020;18(Suppl 1):10-27. DOI: https://doi.org/10.1186/s12963-020-00203-6
Café Oliveira LN, Muniz-Sobrinho Jda S, Viana-Magno LA, Oliveira Melo SC, Macho A, Rios-Santos F. Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes. Braz J Infect Dis. 2016;20(2):166-172. DOI: https://doi.org/10.1016/j.bjid.2015.12.008
Salvato RS, Reis AJ, Schiefelbein SH, Gómez MAA, Salvato SS, da Silva LV, et al. Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil. Int J Antimicrob Agents. 2021;58(4):106401-106409. DOI: https://doi.org/10.1016/j.ijantimicag.2021.106401
IBGE – Instituto Brasileiro de Geografia e Estatística. Censo Brasileiro de 2010. Rio de Janeiro: IBGE; 2022.
Da Silva Oliveira G, Leite Bitencourt E, Ferreira Fernandes Amaral P, Parreira Vaz G, Martins Reis Júnior P, Borges da Costa S. Cobertura vacinal: uma análise comparativa entre os estados da Região Norte do Brasil. Rev Patol Tocantins. 2020;7(1):14-17. DOI: https://doi.org/10.20873/uft.2446-6492.2020v7n1p14
Lima SVMA, dos Santos AD, Duque AM, de Oliveira Goes MA, da Silva Peixoto MV, da Conceição Araújo D, et al. Spatial and temporal analysis of tuberculosis in an area of social inequality in Northeast Brazil. BMC Public Health. 2019;19(1):873-882. DOI: https://doi.org/10.1186/s12889-019-7224-0
Charalambous S, Velen K, Rueda Z, Croda J, Herce ME, Shenoi SV, et al. Scaling up evidence-based approaches to tuberculosis screening in prisons. Lancet Public Health. 2023;8(4):e305-e310. DOI: https://doi.org/10.1016/S2468-2667(23)00002-6
Prado Junior JC, Medronho RA. Spatial analysis of tuberculosis cure in primary care in Rio de Janeiro, Brazil. BMC Public Health. 2021;21(1):1841-1856. DOI: https://doi.org/10.1186/s12889-021-11834-1
Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports. Atlanta. 2020;69(7):1-27. Disponível em: https://www.cdc.gov/mmwr/volumes/69/rr/rr6907a1.htm?s_cid=rr6907a1_w.
Hertz D, Schneider B. Sex differences in tuberculosis. Semin Immunopathol. 2019;41(2):225-237. DOI: https://doi.org/10.1007/s00281-018-0725-6
Mesquita CR, Conceição EC, Monteiro LHMT, da Silva OM, Lima LNGC, de Oliveira RAC, de Brito AC, Guimarães RJPSE, Lima KVB. A Clinical-Epidemiological and Geospatial Study of Tuberculosis in a Neglected Area in the Amazonian Region Highlights the Urgent Need for Control Measures. Int J Environ Res Public Health. 2021 Feb. 2;18(3):1335. DOI: 10.3390/ijerph18031335
Kuan R, Muskat K, Peters B, Lindestam Arlehamn CS. Is mapping the BCG vaccine-induced immune responses the key to improving the efficacy against tuberculosis? J Intern Med. 2020;288(6):651-660. DOI: https://doi.org/10.1111/joim.13191
Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, Bilek N, et al; C-040-404 Study Team. Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination. N Engl J Med. 2018;379(2):138-149. DOI: https://doi.org/10.1056/NEJMoa1714021
Tait DR, Hatherill M, van der Meeren O, Ginsberg AM, van Brakel E, Salaun B, et al. Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis. N Engl J Med. 2019;381(25):2429-2439. DOI: https://doi.org/10.1056/NEJMoa1909953
Scriba TJ, Netea MG, Ginsberg AM. Key recent advances in TB vaccine development and understanding of protective immune responses against Mycobacterium tuberculosis. Semin Immunol. 2020;50:101.431-101.441. DOI: https://doi.org/10.1016/j.smim.2020.101431
Mollel EW, Todd J, Mahande MJ, Msuya SE. Effect of tuberculosis infection on mortality of HIV-infected patients in Northern Tanzania. Trop Med Health. 2020;48:26-36. DOI: https://doi.org/10.1186/s41182-020-00212-z
Mohammed J, North N, Ashton T. Decentralisation of Health Services in Fiji: A Decision Space Analysis. Int J Health Policy Manag. 2015;5(3):173-81. DOI: https://doi.org/10.15171/ijhpm.2015.199
Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-655. DOI: https://doi.org/10.1016/S0140-6736(21)02724-0. Erratum in: Lancet. 2022;400(10358):1102
World Health Organization. Antimicrobial resistance. Geneva: WHO, 2021. Disponível em: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
Campelo TA, Cardoso de Sousa PR, Nogueira LL, Frota CC, Zuquim Antas PR. Revisiting the methods for detecting Mycobacterium tuberculosis: what has the new millennium brought thus far? Access Microbiol. 2021;3(8):000245. DOI: https://doi.org/10.1099/acmi.0.000245 Erratum in: Access Microbiol. 2022;4(1):000294.
Sousa EO, Carneiro RTO, Montes FCOF, Conceição EC, Bartholomay P, Marinho JM, Lima KVB, Natividade MSD, Araújo WN, Matos ED, Barbosa T. Laboratory-based study of drug resistance and genotypic profile of multidrug-resistant tuberculosis isolates in Salvador, Bahia, Brazil. Rev Soc Bras Med Trop. 2022;55:e00132022. DOI: https://doi.org/10.1590/0037-8682-0013-2022
Zhou D, Pender M, Jiang W, Mao W, Tang S. Under-reporting of TB cases and associated factors: a case study in China. BMC Public Health. 2019;19(1):1664-1673. DOI: https://doi.org/10.1186/s12889-019-8009-1
Pescarini JM, Williamson E, Nery JS, Ramond A, Ichihara MY, Fiaccone RL, et al. Effect of a conditional cash transfer program on leprosy treatment adherence and cure in patients from the nationwide 100 Million Brazilian Cohort: a quasi-experimental study. Lancet Infect Dis. 2020;20(5):618-627. DOI: https://doi.org/0.1016/S1473-3099(19)30624-3
World Health Organization. Global Tuberculosis Report 2021. Geneva: WHO, 2021. Disponível em: https://www.who.int/publications/i/item/9789240037021
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