EXTRATO HIDROETANÓLICO DE GENGIBRE (ZINGIBER OFFICINALE) INIBE A OXIDAÇÃO DA LIPOPROTEÍNA DE BAIXA DENSIDADE (LDL), IN VITRO
DOI:
https://doi.org/10.21527/2176-7114.2020.39.19-26Keywords:
Antioxidante. Aterosclerose. Hipercolesterolemia. Produtos Naturais. Estresse Oxidativo.Abstract
Purpose: Considering LDL oxidation as a crucial factor in the development of atherosclerosis, and the antioxidant, anti-inflammatory and anti-angiogenic properties of ginger (Zingiber officinale), the aim of the present study is to evaluate the phytochemical content, antioxidant mechanisms and the potential of Ginger Rhizome Hydroethanolic Extract (EHEG), on low density lipoprotein (LDL) oxidation of hypercholesterolemic patients, in vitro. Method: In EHEG were evaluated contents of phytochemical compounds and antioxidant mechanisms. From patient serum samples (n = 12), the LDL fraction was isolated, previously treated with EHEG (10 - 100 µg / ml) and subjected to oxidative induction with AAPH (10 mM). Afterwards, the lipoperoxidation level was measured. Results: EHEG has total phenolic compounds (357.68 ± 39.80 mg AG / g), flavonoids (30.37 ± 5.10 mg Q / g), tannins (51.99 ± 11.88 mg CA / g ) and vitamin C (21.53 ± 1.43 mg Vit C / g), besides presents NO (IC50 = 40.53 μg / mL) and H2O2 (IC50 = 1.42 mg / mL) radical scavenging activity. Regarding inhibition of LDL oxidation, it was observed that the EHEG, from the concentration of 50 µg/ml was effective in reducing the oxidative damage caused by AAPH. Conclusion: Ginger has protective activity against the formation of oxidized LDL, suggesting that its phytochemical compounds confer antioxidant activity, and may be effective in the prevention and/or treatment of cardiovascular diseases, especially those related to the process of atherosclerosis.
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