Armadilhas Extracelulares Neutrofílicas e Associação a Complicações Pulmonares Graves na Doença Covid-19

Autores/as

DOI:

https://doi.org/10.21527/2176-7114.2023.47.12993

Palabras clave:

NETs; COVID-19; Coronavírus; Lesão Pulmonar.

Resumen

O presente estudo tem como objetivo descrever a associação entre a formação de NETs e o desenvolvimento de agravos pulmonares na Covid-19, bem como explorar o seu desempenho como biomarcador na doença. Trata-se de uma revisão bibliográfica integrativa de literatura, por meio do levantamento de artigos científicos nas bases de dados: PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) e Medical Literature Analysis and Retrieval Sistem On-line (Medline). A partir dos critérios de inclusão e exclusão, foram selecionados 18 artigos para essa revisão. A ativação de neutrófilos e a formação de NETs foram descritos como principais fatores de risco para a mortalidade em pacientes Covid-19. A liberação de NETs correlaciona-se significativamente com a gravidade da patologia pulmonar. Por meio desse estudo conclui-se que formação de NETs excessivos está presente em casos graves de Covid-19 e associada como um biomarcador de diversas complicações, como trombose e coagulopatias.

Citas

Hu B, Guo H, Zhou P, Shi Z-L. Characteristics of SARS-CoV-2 and COVID-19. Nature Reviews Microbiology [Internet]. 2020 Oct. 6;19:1-14. Disponível em: https://www.nature.com/articles/s41579-020-00459-7#citeas

World Health Organization. WHO COVID-19 dashboard [Internet]. World Health Organization; 2021 [cited 2021 Nov. 28]. Disponível em: https://covid19.who.int/

Yaqinuddin A, Kvietys P, Kashir J. COVID-19: Role of neutrophil extracellular traps in acute lung injury. Respiratory Investigation. 2020 Sept.;58(5):419-420.

Radermecker C, Detrembleur N, Guiot J, Cavalier E, Henket M, d’Emal C, et al. Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19. Journal of Experimental Medicine [Internet]. 2020 Sept. 14 [cited 2021 Nov. 28];217(12). Disponível em: https://rupress.org/jem/article/217/12/e20201012/152084/Neutrophil-extracellular-traps-infiltrate-the-lung

Brandão SCS, Godoi ETAM, Ramos J de OX, Melo LMMP de, Sarinho ESC. COVID-19 grave: entenda o papel da imunidade, do endotélio e da coagulação na prática clínica. Jornal Vascular Brasileiro [Internet]. 2020;19. Disponível em: https://www.scielo.br/pdf/jvb/v19/1677-5449-jvb-19-e20200131.pdf

Niedźwiedzka-Rystwej P, Grywalska E, Hrynkiewicz R, Bębnowska D, Wołącewicz M, Majchrzak A, et al. Interplay between Neutrophils, NETs and T-Cells in SARS-CoV-2 Infection – A Missing Piece of the Puzzle in the COVID-19 Pathogenesis? Cells [Internet]. 2021 July 1 [cited 2021 Nov. 28];10(7):1817. Disponível em: https://www.mdpi.com/2073-4409/10/7/1817

Costela-Ruiz VJ, Illescas-Montes R, Puerta-Puerta JM, Ruiz C, Melguizo-Rodríguez L. SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine & Growth Factor Reviews. 2020 Aug;54:62-75.

Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nature Reviews Immunology [Internet]. 2017 Oct. 9 [cited 2019 Feb. 28];18(2):134-147. Disponível em: https://www.nature.com/articles/nri.2017.105

Sollberger G, Tilley DO, Zychlinsky A. Neutrophil Extracellular Traps: The Biology of Chromatin Externalization. Developmental Cell. 2018 Mar;44(5):542-553.

Szturmowicz M, Demkow U. Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease. International Journal of Molecular Sciences. 2021 Aug. 17;22(16):8854.

Silva de Sordi LH, Sales Oliveira Magalhães I, Abreu Casselhas D, Chaves Andrade M. O Papel da Imunidade Inata na COVID-19. Revista Ciências em Saúde. 2020 July 2;10(3):5-8.

Kaplan MJ, Radic M. Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity. The Journal of Immunology [Internet]. 2012 Sep. 6 [cited 2019 Feb. 28];189(6):2689-2.695. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439169/

Boeltz S, Amini P, Anders H-J, Andrade F, Bilyy R, Chatfield S, et al. To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death & Differentiation [Internet]. 2019 Mar. 1 [cited 2021 Nov. 28];26(3):395-408. Disponível em: https://www.nature.com/articles/s41418-018-0261-x

Thierry AR, Roch B. Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy. Journal of Clinical Medicine. 2020 Sep. 11;9(9):2942.

Wang J, Li Q, Yin Y, Zhang Y, Cao Y, Lin X, et al. Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19. Frontiers in Immunology. 2020 Aug. 18;11.

Gustine JN, Jones D. Immunopathology of Hyperinflammation in COVID-19. The American Journal of Pathology. 2020 Sep.

Colling ME, Kanthi Y. COVID-19-associated coagulopathy: An exploration of mechanisms. Vascular Medicine. 2020 Jun. 19;1358863X2093264

Yaqinuddin A, Kashir J. Novel therapeutic targets for SARS-CoV-2-induced acute lung injury: Targeting a potential IL-1β/neutrophil extracellular traps feedback loop. Medical Hypotheses. 2020 Oct.;143:109906.

Chen X, Guo H, Qiu L, Zhang C, Deng Q, Leng Q. Immunomodulatory and Antiviral Activity of Metformin and Its Potential Implications in Treating Coronavirus Disease 2019 and Lung Injury. Frontiers in Immunology. 2020 Aug. 18;11.

Borczuk AC. Pulmonary pathology of COVID-19. Current Opinion in Pulmonary Medicine. 2021 Jan. 4; Publish Ahead of Print.

Lasky JA, Fuloria J, Morrison ME, Lanier R, Naderer O, Brundage T, et al. Design and Rationale of a Randomized, Double-Blind, Placebo-Controlled, Phase 2/3 Study Evaluating Dociparstat in Acute Lung Injury Associated with Severe COVID-19. Advances in Therapy. 2020 Oct. 27;38(1):782-791.

Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, et al. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Medical Hypotheses. 2021 Jan.;146:110394.

Obermayer A, Jakob L-M, Haslbauer JD, Matter MS, Tzankov A, Stoiber W. Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury. Pichler R, editor. Disease Markers [Internet]. 2021 Jul. 30 [cited 2021 Nov. 28];2021:1-10. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34367376/

Pandolfi L, Bozzini S, Frangipane V, Percivalle E, De Luigi A, Violatto MB, et al. Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis. Frontiers in Immunology. 2021 Jun. 14;12.

Latreille E, Lee WL. Interactions of Influenza and SARS-CoV-2 with the Lung Endothelium: Similarities, Differences, and Implications for Therapy. Viruses [Internet]. 2021 Jan 22 [cited 2021 Nov. 28];13(2):161. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33499234/

González-Villalva A, De La Peña-Díaz A, Rojas-Lemus M, López-Valdez N, Ustarroz-Cano M, García-Peláez I, et al. Fisiología de la hemostasia y su alteración por la coagulopatía en COVID-19. Revista de la Facultad de Medicina [Internet]. 2020 [cited 2020 nov. 2];63. Disponível em: https://www.medigraphic.com/pdfs/facmed/un-2020/un205h.pdf

Publicado

2023-11-30

Cómo citar

de Andrade, G., Oyczenascz, B. L. S., & Frizzo, M. N. (2023). Armadilhas Extracelulares Neutrofílicas e Associação a Complicações Pulmonares Graves na Doença Covid-19. Revista Contexto &Amp; Saúde, 23(47), e12993. https://doi.org/10.21527/2176-7114.2023.47.12993

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