EFFECTS OF THE INGESTION OF FLAXSEED (LINUM USITATISSIMUM L.) OIL AND PHYSICAL EXERCISE ON THE BODY WEIGHT, GLYCEMIC AND LIPID PROFILES OF A RAT MODEL DEVELOPED FOR THE STUDY OF METABOLIC SYNDROME

EFEITOS DA INGESTÃO DE ÓLEO DE LINHAÇA (LINUM USITATISSIMUM L.) E EXERCÍCIO FÍSICO EM MODELO ANIMAL PARA SÍNDROME METABÓLICA

Authors

  • Carlos Alexandre Molena Fernandes Docente do Programa de Programa de Pós-Graduação em Enfermagem - Universidade Estadual de Maringá – UEM. Docente do Curso de Educação Física - Universidade Estadual do Paraná – UNESPAR – Paranavaí- PR. http://orcid.org/0000-0002-4019-8379
  • Karine Oltramari Prefeitura Municipal de Curitiba. Doutorado em Ciência de Alimentos - Universidade Estadual de Maringá http://orcid.org/0000-0002-1383-1765
  • Nelson Nardo Junior Docente do Departamento de Educação Física da Universidade Estadual de Maringá e do Programa de Pós-Graduação Associado em Educação Física UEM/UEL - Universidade Estadual de Maringá – Maringá – PR. http://orcid.org/0000-0002-6862-7868
  • Greice Westphal Doutoranda do Programa de Pós-Graduação Associado em Educação Física UEM/UEL – Universidade Estadual de Maringá – Maringá – PR. http://orcid.org/0000-0001-9107-0108

DOI:

https://doi.org/10.21527/2176-7114.2021.43.11623

Keywords:

Metabolic syndrome, flaxseed oil, physical exercise, glucose intolerance, spontaneously hypertensive rats

Abstract

Metabolic syndrome (MetSyn) is a disorder that involves a series of symptoms that are associated to obesity and metabolic modifications, and increases the risk of developing cardiovascular disease and type 2 diabetes Mellitus. The study of new possibilities of non-drug therapies is fundamental for the primary prevention of MetSyn. The aim of this work was to evaluate the responses of spontaneously hypertensive rats (SHR) with lipid changes induced by the administration of dexamethasone (DEXA) to the ingestion of flaxseed oil associated or not associated with physical exercise regarding the body weight, and glycemic and lipid profiles, in comparison with the drug treatment with metformin. After 24 days of experiment, the 20-week-old animals were submitted to the glucose tolerance test (GTT) and lipid profile evaluation. The results showed that the administration of DEXA in SHR animals promoted a framework of hyperglycemia, dyslipidemia and attenuated the insulin resistance common in the SHR, thus producing an experimental model with several components of the human MetSyn. The effects on weight gain indicated an important preventive action of flaxseed oil and exercise on the weight evolution of SHR-DEXA animals. Furthermore, the ingestion of flaxseed oil associated or not with exercise promoted significant improvements on hyperglycemia and glucose intolerance in these animals. Regarding the lipid profile, the treatments with flaxseed oil and exercise promoted reductions in triglyceride levels and HDL-c increase; however, the combination of these two non-drug interventions was more effective than the isolated treatments.

Author Biographies

Carlos Alexandre Molena Fernandes, Docente do Programa de Programa de Pós-Graduação em Enfermagem - Universidade Estadual de Maringá – UEM. Docente do Curso de Educação Física - Universidade Estadual do Paraná – UNESPAR – Paranavaí- PR.

Graduate Director of the State University of Paraná - UNESPAR. Graduated in Physical Education from the State University of Maringá (2003), Specialization in Promotion of Men's Health (2004), Master in Health Sciences from the State University of Maringá (2006) and Doctorate in Pharmaceutical Sciences from the State University of Maringá (2010 ). Adjunct Professor C at UNESPAR (Paraná State University - Paranavaí Campus). He is currently a permanent professor in the Stricto Sensu Graduate Program (Master and Doctorate in Nursing) at the State University of Maringá - UEM. Minister the Disciplines of Exercise Physiology; Sports nutrition; Epidemiology, Biostatistics and Non-Pharmacological Prevention and Treatment of Chronic Diseases. Leader of the NEPEMAAS Research Group (Center for Multidisciplinary Studies and Research in Policies, Evaluation and Health Care). Has experience in the area of ​​Collective Health, with emphasis on Promotion of Men's Health, acting mainly on the following themes: Epidemiology, Natural Products, Chronic Diseases (Diabetes, Hypertension, Obesity and Metabolic Syndrome), Physical Activity and Health and Exercise Physiology.

Karine Oltramari, Prefeitura Municipal de Curitiba. Doutorado em Ciência de Alimentos - Universidade Estadual de Maringá

Graduated in Nutrition from the State University of the Midwest (2008), master's degree from the Postgraduate Program in Health Sciences from the State University of Maringá and doctorate in Food Science (UEM), working mainly on the following themes: food and nutrition security , nutrition education, obesity, chronic non-communicable diseases, functional foods, resistant starch, new product development, microbiological quality. Currently participates as a nutritionist and technical support at the Center for Multiprofessional Studies on Obesity (NEMO), at the State University of Maringá (UEM).

Nelson Nardo Junior, Docente do Departamento de Educação Física da Universidade Estadual de Maringá e do Programa de Pós-Graduação Associado em Educação Física UEM/UEL - Universidade Estadual de Maringá – Maringá – PR.

Graduated in Physical Education from Universidade Estadual Paulista Júlio de Mesquita Filho - FCT - Pres. Prudente-SP (1994), master's degree in Motricity Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho - IB - Rio Claro-SP (1998) and doctorate in Applied Human Nutrition from the University of São Paulo (2005). In 2011-2012, he did a postdoctoral internship at the University of Ottawa-Canada at the Behavioral and Metabolic Research Unit and in 2015 at the Research Institute of Children's Hospital of Eastern Ontario. Associate professor at the State University of Maringá, Coordinator of the Associate Postgraduate Program in Physical Education UEM / UEL in the period 2012-2014, Coordinator of the Center for Multiprofessional Studies on Obesity (NEMO) and member of the Canadian Obesity Network (CON). Deputy director of the Health Sciences Center at the State University of Maringá (2016-2020). He has experience in the area of ​​Physical Education, with emphasis on the area of ​​Physical Activity related to Health, acting mainly on the following themes: Health Promotion, prevention and treatment of chronic non-communicable diseases, multiprofessional treatment of obesity and associated diseases, physical activity, fitness physical, body composition and metabolic control.

Greice Westphal, Doutoranda do Programa de Pós-Graduação Associado em Educação Física UEM/UEL – Universidade Estadual de Maringá – Maringá – PR.

Regular PhD student by the Associate Postgraduate Program in Physical Education UEM / UEL. Scholarship ATP-A / CNPQ Project: 443353 / 2016-6 Efficacy Test of an Orientation Program for Changing Eating Habits and Physical Activity in Adults with Overweight and Abdominal Obesity in Three South American Countries: BRAASUL Study, linked to State University of Maringá, by the Center for Multiprofessional Studies on Obesity-NEMO / HUM / UEM. Master by the Human Movement Sciences Course at the Faculty of Health Sciences, by the Methodist University of Piracicaba (2017) - Research line Functional Evaluation and Rehabilitation - He was a fellow at: Coordination for the Improvement of Higher Education Personnel (CAPES) . Specialist in School Physical Education, Recreation, Exercise Physiology and Health by Associação Catarinense de Ensino Faculdade Guilherme Guimbala (2011). Graduated in Physical Education from the University of Vale do Itajaí (2010). Currently participates in the Center for Multiprofessional Studies on Obesity (NEMO) at the State University of Maringá (UEM) as a member of the research group. She is a member of the Canadian Obesity Network (CON). She is Engagement Coordinator in the program “Optimizing the Treatment and Management of Obesity (OPTiMO)” in partnership with MDBriefCase, in Toronto - Canada. Technical fellow from the NEMO laboratory for the project: Test of the effectiveness of an orientation program for changing eating habits and physical activity in overweight and abdominal obesity adults from three countries in South America: BRAASUL Study (Colombia, Brazil and Chile) . He works mainly on the following themes: Obesity, Exercise Physiology, Functional Evaluation and Rehabilitation and Physical Activity.

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Published

2021-10-04

How to Cite

Molena Fernandes, C. A., Oltramari, K., Nardo Junior, N., & Westphal, G. (2021). EFFECTS OF THE INGESTION OF FLAXSEED (LINUM USITATISSIMUM L.) OIL AND PHYSICAL EXERCISE ON THE BODY WEIGHT, GLYCEMIC AND LIPID PROFILES OF A RAT MODEL DEVELOPED FOR THE STUDY OF METABOLIC SYNDROME: EFEITOS DA INGESTÃO DE ÓLEO DE LINHAÇA (LINUM USITATISSIMUM L.) E EXERCÍCIO FÍSICO EM MODELO ANIMAL PARA SÍNDROME METABÓLICA. Context and Health Journal, 21(43), 165–179. https://doi.org/10.21527/2176-7114.2021.43.11623

Issue

Vol. 21 No. 43 (2021): jul-set

Section

Exercício Físico & Saúde

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