Assessment of delirium incidence in critically ill patients using the confusion assessment method for intensive care units
DOI:
https://doi.org/10.21527/2176-7114.2026.51.17196Keywords:
Delirium, Intensive Care Units, Health care evaluation, Incidence, Evaluation scalesAbstract
Objective: To determine the incidence of delirium in critically ill users admitted to the intensive care unit (ICU) and analyze its association with clinical and therapeutic variables using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Methods: This prospective, analytical, observational study included 108 adult ICU users. Data were collected using clinical forms and the CAM-ICU tool, administered by trained physiotherapists. The investigated variables included sex, age, length of hospitalization, type of admission, sedation, mechanical ventilation, and the occurrence of delirium. Associations were tested using the chi-square test at a significance level of 5 %. Results: Delirium was identified in 29.6% of users. A statistically significant association was found between delirium and the use of sedation (P = 0.010) and mechanical ventilation (P < 0.001). Users receiving mechanical ventilation were 5.65 times more likely to develop delirium, and those diagnosed with delirium had longer hospital stays. Conclusion: Sedation and mechanical ventilation were significantly associated with delirium in critically ill users. These findings reinforce the need for preventive measures, routine delirium monitoring, and multidisciplinary management strategies to minimize adverse outcomes during ICU stays.
References
1. Mart MF, Williams Roberson S, Salas B, Pandharipande PP, Ely EW. Prevention and Management of Delirium in the Intensive Care Unit. Semin Respir Crit Care Med. 2021 Feb 3;42(01):112–26.
2. Witlox J, Eurelings LSM, de Jonghe JFM, Kalisvaart KJ, Eikelenboom P, van Gool WA. Delirium in older adult patients and the risk of post-discharge mortality, institutionalization, and dementia. JAMA. 2010 Jul 28;304(4):443.
3. Herling SF, Greve IE, Vasilevskis EE, Egerod I, Bekker Mortensen C, Møller AM, et al. Interventions for preventing intensive care unit delirium in adults. Cochrane Database of Systematic Reviews. 2018 Nov 23;2019(1).
4. Mori S, Takeda JRT, Carrara FSA, Cohrs CR, Zanei SSV, Whitaker IY. Incidence and factors related to delirium in an intensive care unit. Revista da Escola de Enfermagem da USP. 2016 Aug;50(4):587–93.
5. Milbrandt EB, Deppen S, Harrison PL, Shintani AK, Speroff T, Stiles RA, et al. Costs associated with delirium in mechanically ventilated patients*. Crit Care Med. 2004 Apr;32(4):955–62.
6. Faisal H, Farhat S, Grewal NK, Masud FN. ICU Delirium in Cardiac Patients. Methodist Debakey Cardiovasc J. 2023 Aug 1;19(4):74–84.
7. Gusmao-Flores D, Salluh JIF, Chalhub RÁ, Quarantini LC. The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care. 2012 Jul 3;16(4):R115.
8. Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, et al. Delirium in Mechanically Ventilated Patients. JAMA. 2001 Dec 5;286(21):2703.
9. Stollings JL, Kotfis K, Chanques G, Pun BT, Pandharipande PP, Ely EW. Delirium in critical illness: clinical manifestations, outcomes, and management. Intensive Care Med. 2021 Oct 16;47(10):1089–103.
10. Ely EW, Pun BT. Confusion Assessment Method for the ICU (CAM-ICU): the complete training manual. Revised ed Aug. 2016;31.
11. Chaiwat O, Chanidnuan M, Pancharoen W, Vijitmala K, Danpornprasert P, Toadithep P, et al. Postoperative delirium in critically ill surgical patients: incidence, risk factors, and predictive scores. BMC Anesthesiol. 2019 Dec 20;19(1):39.
12. Bose S, Kelly L, Shahn Z, Novack L, Banner‐Goodspeed V, Subramaniam B. Sedative polypharmacy mediates the effect of mechanical ventilation on delirium in critically ill COVID ‐19 patients: A retrospective cohort study. Acta Anaesthesiol Scand. 2022 Oct 18;66(9):1099–106.
13. Rahimi-Bashar F, Abolhasani G, Manouchehrian N, Jiryaee N, Vahedian-Azimi A, Sahebkar A. Incidence and Risk Factors of Delirium in the Intensive Care Unit: A Prospective Cohort. Biomed Res Int. 2021 Jan 8;2021(1).
14. Mohsen S, Moss SJ, Lucini F, Krewulak KD, Stelfox HT, Niven DJ, et al. Impact of Family Presence on Delirium in Critically Ill Patients: A Retrospective Cohort Study*. Crit Care Med. 2022 Nov 26;50(11):1628–37.
15. Salluh JIF, Wang H, Schneider EB, Nagaraja N, Yenokyan G, Damluji A, et al. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ. 2015 Jun 3;350(may19 3):h2538–h2538.
16. Vasilevskis EE, Chandrasekhar R, Holtze CH, Graves J, Speroff T, Girard TD, et al. The Cost of ICU Delirium and Coma in the Intensive Care Unit Patient. Med Care. 2018 Oct;56(10):890–7.
17. Duprey MS, van den Boogaard M, van der Hoeven JG, Pickkers P, Briesacher BA, Saczynski JS, et al. Association between incident delirium and 28- and 90-day mortality in critically ill adults: a secondary analysis. Crit Care. 2020 Dec 20;24(1):161.
18. Inouye SK, Westendorp RGJ, Saczynski JS. Delirium in elderly people. The Lancet [Internet]. 2014 Mar 8;383(9920):911–22. Available from: https://doi.org/10.1016/S0140-6736(13)60688-1
19. Dunne SS, Coffey JC, Konje S, Gasior S, Clancy CC, Gulati G, et al. Biomarkers in delirium: A systematic review. J Psychosom Res. 2021 Aug;147:110530.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Gabrielle Louzada de Souza Corrêa, Laryssa Pani Schrioder, Jaqueline Benaquio, Clairton Marcolongo Pereira, Sarah Fernandes Teixeira, Michelle Lima Garcez, Tatiani Bellettini dos Santos, Fernanda Cristina de Abreu Quintela Castro

This work is licensed under a Creative Commons Attribution 4.0 International License.
By publishing in Revista Contexto & Saúde, authors agree to the following terms:
The works are licensed under the Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) license, which allows:
Share — to copy and redistribute the material in any medium or format;
Adapt — to remix, transform, and build upon the material for any purpose, including commercial.
These permissions are irrevocable, provided that the following terms are respected:
Attribution — authors must be properly credited, with a link to the license and indication of any changes made.
No additional restrictions — no legal or technological measures may be applied that restrict the use permitted by the license.
Notes:
The license does not apply to elements in the public domain or covered by legal exceptions.
The license does not grant all rights necessary for specific uses (e.g., image rights, privacy, or moral rights).
The journal is not responsible for opinions expressed in the articles, which are the sole responsibility of the authors. The Editor, with the support of the Editorial Board, reserves the right to suggest or request modifications when necessary.
Only original scientific articles presenting research results of interest that have not been published or simultaneously submitted to another journal with the same objective will be accepted.
Mentions of trademarks or specific products are intended solely for identification purposes, without any promotional association by the authors or the journal.
License Agreement (for articles published from September 2025): Authors retain copyright over their article and grant Revista Contexto & Saúde the right of first publication.